Deng Pan Lab at Tsinghua University 

Welcome to the Deng Pan Lab! Our research focuses on understanding cancer immune evasion mechanisms and identification of novel cancer immunotherapy target.  Through cutting-edge functional genomic approaches and by establishing various in vitro and in vivo screening assays, we investigate the pathways employed by tumor cells to thwart elimination by different types of immune cells, such as CD8+ T cells, NK cells, and macrophages (Wu et al., Cell Metabolism, In Press; Pan et al., Science, 2018; Ito et al., Cancer Discovery 2023). The lab also develops functional screens in various types of tumor-infiltrating immune cells, including major lymphoid and myeloid lineages. Through genetic perturbations in both tumor and immune cells, the lab’s goal is to gain a comprehensive understanding of immune evasion mechanisms, paving the way for the development of novel and effective strategies in cancer immunotherapy.